How the treatments work
Plain-English explainers on GLP-1 weight-loss medicines — what they are, how they work, and what the evidence actually shows.
Orforglipron Weight Loss: The ATTAIN-1 Trial Results
How much weight did people lose on orforglipron? In the Phase 3 ATTAIN-1 trial, participants on 36mg lost 12.4% of body weight over 72 weeks.
Read article →How Orforglipron Works: The First Small-Molecule GLP-1 Pill
How orforglipron works: the small-molecule GLP-1 pill explained — mechanism, why it survives digestion, and how it differs from peptide GLP-1 medicines.
Read article →MHRA Authorises Orforglipron: What It Actually Means
The MHRA authorised orforglipron (Foundayo) on 10 August 2026. Here's what a UK marketing authorisation actually means — and why it isn't the same as availability.
Read article →Is Foundayo (Orforglipron) Available in the UK?
Foundayo (orforglipron) has a UK marketing authorisation, but that isn't the same as availability. Here's what UK approval actually means in 2026.
Read article →How Long Does Mounjaro Take to Work? What to Expect Week by Week
How long does Mounjaro take to work? Most people notice reduced appetite within days and steady weight loss over weeks. A UK pharmacist's week-by-week timeline.
Read article →What Are GLP-1 Medications? A Plain-English Guide to How They Work
A plain-English guide to GLP-1 weight-loss medicines: how Wegovy and Mounjaro work, who they're licensed for in the UK, trial results, and the balanced safety picture.
Read article →Medical Weight Loss in the UK: Separating the Myths from the Facts
A clear, balanced guide to prescription weight-loss medicines in the UK — separating myth from evidence on Mounjaro and Wegovy, who they suit, and safe, regulated treatment.
Read article →Weight Loss Without Dieting: What the Science Actually Says
Why willpower alone rarely works, how appetite hormones drive overeating, and where prescription GLP-1 medicines like Mounjaro and Wegovy fit in. UK pharmacy guide.
Read article →Weight Loss Injections in the UK: How GLP-1 Medicines Work
A plain-English guide to weight loss injections in the UK: how Mounjaro and Wegovy work, who is eligible, realistic results, dosing, and side effects and safety.
Read article →Ready to see if treatment is right for you? Free eligibility check — reviewed by a GPhC-registered prescriber.
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