Yes — if you are on a weekly weight-loss injection, you can usually switch to the once-daily Wegovy Tablet (oral semaglutide) after a 7-day gap from your last weekly injection. The tablet contains the same active medicine as the Wegovy injection; your prescriber chooses your starting tablet dose based on the injection dose you are on now, how well you have tolerated it, and your medical history.
This is a guide, not a prescription. The tables below show how injection and tablet doses are commonly matched — but the right dose for you is always a decision made with your prescriber, who may start you lower, or move more slowly, than the tables suggest.
Why people move to the tablet
The Wegovy Tablet appeals to people who would rather not inject. It is the same GLP-1 medicine (semaglutide) as the Wegovy injection, taken as a once-daily tablet instead of a weekly jab. There is a trade-off: the tablet has to be taken correctly to work — first thing in the morning, on an empty stomach, with a small sip of plain water, then nothing to eat, drink or take for at least 30 minutes. You can read the full routine on our Wegovy Tablet page.
Equivalent strengths: Wegovy injection to Wegovy Tablet
If you are already on the Wegovy (semaglutide) injection, the tablet strength most often used as a like-for-like starting point is shown below. Because it is the same medicine, this switch is the most straightforward.
| Wegovy injection — weekly | Wegovy Tablet — daily |
|---|---|
| 0.25 mg | 4 mg |
| 0.5 mg | 4 mg |
| 1 mg | 9 mg |
| 1.7 mg | 9 mg |
| 2.4 mg | 25 mg |
| 7.2 mg | 25 mg |
The Wegovy Tablet is usually started at a 1.5 mg introductory dose and stepped up (4 mg, 9 mg, then 25 mg) roughly every four weeks. If you are already established on a higher injection dose, your prescriber may bring you in above the 1.5 mg starter — but that is their call, based on how you have tolerated treatment so far.
Equivalent strengths: Mounjaro injection to Wegovy Tablet
Mounjaro (tirzepatide) and the Wegovy Tablet (semaglutide) are different medicines that work in slightly different ways — Mounjaro acts on two gut-hormone receptors, semaglutide on one. There is therefore no exact dose-for-dose equivalent. The table below is only an approximate reference point a prescriber may use as a starting position when moving someone across; it is common to begin more cautiously.
| Mounjaro injection — weekly | Wegovy Tablet — daily (approx.) |
|---|---|
| 2.5 mg | 9 mg |
| 5 mg | 9 mg |
| 7.5 mg | 25 mg |
| 10 mg | 25 mg |
| 12.5 mg | 25 mg |
| 15 mg | 25 mg |
Because these are different drugs, your prescriber may choose to hold you at a lower tablet dose for longer while your body adjusts. Do not use this table to self-select a dose.
How the switch works in practice
- A 7-day washout is required first. Because the weekly injection is long-acting, you wait 7 days after your last injection before taking your first daily tablet, so the two do not overlap. Your prescriber will confirm the exact timing.
- Take it correctly. One tablet each morning on an empty stomach with a small sip of plain water, then wait at least 30 minutes before eating, drinking anything else, or taking other medicines. Taken with food it is far less effective.
- Step up gradually. The dose is normally increased about every four weeks, as long as you are tolerating it, until you reach the dose your prescriber is aiming for.
Side effects to expect
The tablet has the same GLP-1 class side-effect profile as the injections. The most common effects are nausea, diarrhoea, constipation and reduced appetite, especially when a dose goes up; they usually settle. Rare but serious effects include pancreatitis and severe allergic reactions — seek medical advice if you are unwell. You can report a suspected side effect through the MHRA Yellow Card scheme at https://yellowcard.mhra.gov.uk/.
How well does the tablet work?
The injection and the tablet have been studied in separate trials, so the figures below are not a head-to-head comparison. In the OASIS 4 trial, adults on oral semaglutide 25 mg lost on average 16.6% of their body weight over 64 weeks, alongside lifestyle support. Individual results vary; not everyone reaches this. For context, the Wegovy injection reported 20.7% at the 7.2 mg dose (STEP UP trial) and Mounjaro 22.5% at 15 mg (SURMOUNT-1 trial) — again, individual results vary; not everyone reaches this, and these come from different studies.
Is the Wegovy Tablet right for you?
Weight-loss medicines are generally considered for adults with a BMI of 30 or more, or 27 or more with a weight-related condition such as type 2 diabetes, high blood pressure or sleep apnoea. They are prescription-only and are prescribed only if clinically appropriate after a consultation with a GPhC-registered prescriber — a prescription is never guaranteed. If you are thinking about switching, the simplest next step is a free online eligibility check, and your prescriber can talk the change through with you.
This article is for information only and is not a substitute for personalised medical advice. Weight-loss medicines are prescription-only, are not suitable for everyone, and are prescribed only after a clinical consultation with a GPhC-registered prescriber. Individual results vary. Always speak to a UK-registered pharmacist or doctor before starting or changing any prescription medication.
